Gliocidin

Name: Gliocidin
Brand: Tocris Bioscience
SKU: 8893

Tocris Bioscience, part of Bio-Techne | Catalog # 8893

COA / SDS

IMPDH2 (inosine monophosphate dehydrogenase 2) inhibitor, also glioblastoma targeting Nicotinamide mimetic prodrug

Key Product Details

Description:	IMPDH2 (inosine monophosphate dehydrogenase 2) inhibitor, also glioblastoma targeting Nicotinamide mimetic prodrug
Chemical Name:	N-3-Pyridinyl-2-thiophenecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	204.25

View Full Technical Details for Gliocidin

Technical Data
Citations

Biological Activity for Gliocidin

Gliocidin is an IMPDH2 (inosine monophosphate dehydrogenase 2) inhibitor. Gliocidin is a nicotinamide-mimetic prodrug that is anabolized into its tumoricidal metabolite, gliocidin-adenine dinucleotide (GAD). Gliocidin kills glioblastoma cells while sparing non-tumour replicative cells. In vivo, Gliocidin penetrates the blood-brain barrier and extends the survival of mice with orthotopic glioblastoma.

Technical Data for Gliocidin

M. Wt	204.25
Formula	C₁₀H₈N₂OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	62289-81-0
PubChem ID	790407
InChi Key	UPLHUDRMLWWFRE-UHFFFAOYSA-N
Smiles	O=C(NC=1C=NC=CC1)C=2SC=CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Gliocidin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.43	100
	ethanol	20.43	100

Preparing Stock Solutions for Gliocidin

The following data is based on the product molecular weight 204.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.90 mL	24.48 mL	48.96 mL
5 mM	0.98 mL	4.90 mL	9.79 mL
10 mM	0.49 mL	2.45 mL	4.90 mL
50 mM	0.10 mL	0.49 mL	0.98 mL

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Reconstitution Calculator

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References for Gliocidin

References are publications that support the biological activity of the product.

Chen Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma. Nature 2024 PMID: 39567689