Glibenclamide is an ATP-dependent K⁺ channel (K_ir6, K_ATP) and CFTR Cl^- channel blocker. Inhibits K_ir6 currents in the pancreas, by binding to the SUR1 regulatory subunit, causing an increase in intracellular Ca²⁺ and insulin secretion. Inhibits recombinant CFTR Cl^- channels with an IC₅₀ of 20 μM.

Product Specifications

Molecular Weight

494.00

Formula

C₂₃H₂₈ClN₃O₅S

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide

CAS Number

10238-21-8

PubChem ID

3488

InChI Key

ZNNLBTZKUZBEKO-UHFFFAOYSA-N

SMILES

COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	Ethanol	5

Preparing Stock Solutions for Glibenclamide

The following data is based on the product molecular weight 494.00

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.12 mL	20.24 mL
5 mM	0.40 mL	2.02 mL	4.05 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Robertson Potassium channel modulators: scientific applications and therapeutic promise. J.Med.Chem. 1990 PMID: 2187993
Sheppard and Welsh Effect of ATP-sensitive K⁺ channel regulators on cystic fibrosis transmembrane conductance regulator chloride channels. J.Gen.Physiol. 1992 PMID: 1281220
Brogden Glibenclamide: a review. Drugs 1979 PMID: 389600

Glibenclamide

Tocris Bioscience, part of Bio-Techne | Catalog # 0911

Key Product Details

Description

Alternative Names

View all Inward Rectifier Potassium Channel Blockers »

Product Description