GKA 50
Tocris Bioscience, part of Bio-Techne | Catalog # 5133
Glucokinase activator
Product Description
GKA 50 is a potent glucokinase activator (EC50 = 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.Product Specifications
Molecular Weight
464.51
Formula
C26H28N2O6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid
CAS Number
851884-87-2
PubChem ID
11340230
InChI Key
OCBMECSFDVUYQN-ROUUACIJSA-N
SMILES
O=C(NC3=NC=C(C(O)=O)C=C3)C1=CC(O[C@@H](C)COC)=CC(O[C@@H](C)CC2=CC=CC=C2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.45 | 100 |
Preparing Stock Solutions
for GKA 50
The following data is based on the product molecular weight 464.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.15 mL | 10.76 mL | 21.53 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.31 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.15 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Johnson Glucokinase activators: molecular tools for studying the physiology of Ins-Secr.g cells. Biochem.Soc.Trans. 2007 PMID: 17956314
- Coope Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats. Br.J.Pharmacol. 2006 PMID: 16921397
Product Specific Notices for GKA 50
For research use only
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