GGTI 298

Tocris Bioscience, part of Bio-Techne | Catalog # 2430

Geranylgeranyltransferase I (GGTase I) inhibitor
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Key Product Details

Description

Geranylgeranyltransferase I (GGTase I) inhibitor

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Product Description

GGTI 298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor. Strongly inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50 values are 3 and > 10 μM respectively). Causes G0-G1 cell cycle block and apoptosis in A549 cells and inhibits cell invasion and migration in COLO 320CM cells.

Product Specifications

Molecular Weight

593.66

Formula

C27H33N3O3S.CF3CO2H

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine methyl ester trifluoroacetate salt

CAS Number

1217457-86-7

PubChem ID

16078971

InChI Key

WALKWJPZELDSKT-UFABNHQSSA-N

SMILES

SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@@](OC)=O)CC(C)C)=O)C(C2=CC=CC3=C2C=CC=C3)=C1.FC(F)(C(O)=O)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.84 25

Preparing Stock Solutions for GGTI 298

The following data is based on the product molecular weight 593.66

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 6.74 mL 33.69 mL 67.38 mL
1.25 mM 1.35 mL 6.74 mL 13.48 mL
2.5 mM 0.67 mL 3.37 mL 6.74 mL
12.5 mM 0.13 mL 0.67 mL 1.35 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for GGTI 298

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for GGTI 298

For research use only

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