GeA-69
Tocris Bioscience, part of Bio-Techne | Catalog # 6795
Selective allosteric PARP14 inhibitor
Key Product Details
Description
Selective allosteric PARP14 inhibitor
Product Description
GeA-69 is a selective allosteric inhibitor of poly (ADP-ribose) polymerase 14 (PARP14) macrodomain 2 (MD2) (IC50 = 720 nM, Kd = 860 nM). It inhibits adenosine diphosphate ribose (ADPR) binding to the macrodomain 2 of PARP14 and prevents PARP14 MD2 localization to DNA damage sites in intact cells. GeA-69 is highly cell permeable.Product Specifications
Molecular Weight
300.35
Formula
C20H16N2O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-(9H-Carbazol-1-yl)phenyl]acetamide
CAS Number
2143475-98-1
PubChem ID
135397654
InChI Key
LDPDVNYCIOHPGF-UHFFFAOYSA-N
SMILES
O=C(NC=1C=CC=CC1C=2C=CC=C3C=4C=CC=CC4NC23)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.03 | 100 | |
| Ethanol | 15.02 | 50 |
Preparing Stock Solutions
for GeA-69
The following data is based on the product molecular weight 300.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.33 mL | 16.65 mL | 33.29 mL |
| 5 mM | 0.67 mL | 3.33 mL | 6.66 mL |
| 10 mM | 0.33 mL | 1.66 mL | 3.33 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Moustakim Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2. Bioorg.Med.Chem. 2018 PMID: 29567296
- Schuller Discovery of a selective allosteric inhibitor targeting macrodomain 2 of polyadenosine-diphosphate-ribose polymerase 14. ACS Chem.Biol. 2017 PMID: 28991428
Product Specific Notices for GeA-69
For research use only
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