GDC 0941
Tocris Bioscience, part of Bio-Techne | Catalog # 8905
Potent pan-class I PI3 kinase inhibitor
Key Product Details
Description
Potent pan-class I PI3 kinase inhibitor
Product Description
GDC 0941 is a potent pan PI3K inhibitor of class I catalytic subunits p110α, δ, β, and γ (IC50 values are 3, 3, 33 and 75 nM, respectively). GDC 0941 inhibits the PI3K/AKT/mTOR signaling pathways and tumor cell growth in vitro and in vivo. GDC 0941 can be used in stem cell differentiation protocols to generate artery and vein endothelial cells from PSCs. GDC 0941 is orally bioavailable.Product Specifications
Molecular Weight
513.64
Formula
C23H27N7O3S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine
CAS Number
957054-30-7
PubChem ID
17755052
InChI Key
LHNIIDJUOCFXAP-UHFFFAOYSA-N
SMILES
O=S(=O)(N1CCN(CC=2SC3=C(N=C(N=C3N4CCOCC4)C=5C=CC=C6NN=CC65)C2)CC1)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.36 | 100 |
Preparing Stock Solutions
for GDC 0941
The following data is based on the product molecular weight 513.64
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.95 mL | 9.73 mL | 19.47 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.89 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.95 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Loh Protocol for efficient generation of human artery and vein endothelial cells from pluripotent stem cells. STAR Protoc. 2025 PMID: 39705146
- Folkes The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J.Med.Chem. 2008 PMID: 18754654
- Ang Generating human artery and vein cells from pluripotent stem cells highlights the arterial tropism of Nipah and Hendra viruses. Cell 2022 PMID: 35738284
Product Specific Notices for GDC 0941
For research use only
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