Galeterone
Tocris Bioscience, part of Bio-Techne | Catalog # 6108
CYP17 inhibitor; also androgen receptor antagonist
Key Product Details
Description
CYP17 inhibitor; also androgen receptor antagonist
Alternative Names
TOK-001,VN/124-1
Product Description
Galeterone is a CYP17 inhibitor (IC50 = 300 nM) and androgen receptor antagonist (IC50 = 384 nM in PC3-AR cells). Inhibits DHT-stimulated prostate cancer cell proliferation in vitro. Exhibits antitumor activity in SCID mice bearing prostate cancer xenografts.Product Specifications
Molecular Weight
388.55
Formula
C26H32N2O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(3β)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol
CAS Number
851983-85-2
PubChem ID
11188409
InChI Key
PAFKTGFSEFKSQG-PAASFTFBSA-N
SMILES
[H][C@@]12CC=C([C@]1(CC[C@]3([C@]2(CC=C4C[C@H](CC[C@]34C)O)[H])[H])C)N5C=NC6=CC=CC=C56
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.43 | 50 | |
| Ethanol | 19.43 | 50 |
Preparing Stock Solutions
for Galeterone
The following data is based on the product molecular weight 388.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.15 mL | 25.74 mL | 51.47 mL |
| 2.5 mM | 1.03 mL | 5.15 mL | 10.29 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.15 mL |
| 25 mM | 0.10 mL | 0.51 mL | 1.03 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Handratta Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. J.Med.Chem. 2005 PMID: 15828836
- Njar & Brodie Discovery and development of Galeterone (TOK-001 or VN/124-1) for the treatment of all stages of prostate cancer. J.Med.Chem. 2015 PMID: 25591066
Product Specific Notices for Galeterone
For research use only
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