Galanthamine hydrobromide
Tocris Bioscience, part of Bio-Techne | Catalog # 0686
Cholinesterase inhibitor
Product Description
Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Long-term administration reduces amyloid precursor protein deposition and neurodegeneration in a mouse model of Alzheimer's disease.Product Specifications
Molecular Weight
368.27
Formula
C17H21NO3.HBr
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
CAS Number
1953-04-4
PubChem ID
121587
InChI Key
QORVDGQLPPAFRS-XPSHAMGMSA-N
SMILES
O[C@H]1C=C[C@]([C@]2=C(O4)C(OC)=CC=C2CN(CC3)C)3[C@@H]4C1.Br
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.37 | 20 | |
| DMSO | 7.37 | 20 with gentle warming |
Preparing Stock Solutions
for Galanthamine hydrobromide
The following data is based on the product molecular weight 368.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.58 mL | 67.88 mL | 135.77 mL |
| 1 mM | 2.72 mL | 13.58 mL | 27.15 mL |
| 2 mM | 1.36 mL | 6.79 mL | 13.58 mL |
| 10 mM | 0.27 mL | 1.36 mL | 2.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sweeney Galanthamine, an acetylcholinesterase inhibitor: a time course of the effects on performance and neurochemical parameters in mice. Pharmacol.Biochem.Behav. 1989 PMID: 2626444
- Samochocki Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 2003 PMID: 12649296
- Capsoni Nerve growth factor and galant. ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc.Natl.Acad.Sci.U.S.A. 2002 PMID: 12205295
- Harvey The pharmacology of galanthamine and its analogues. Pharmacol.Ther. 1995 PMID: 8604434
- Arias Galantamine prevents apoptosis induced by β-amyloid and thapsigargin: involvement of nicotinic acetycholine receptors. Neuropharmacology 2004 PMID: 14654102
Product Specific Notices for Galanthamine hydrobromide
For research use only
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