Galangin

Name: Galangin
Brand: Tocris Bioscience
SKU: 6494

Tocris Bioscience, part of Bio-Techne | Catalog # 6494

COA / SDS

TRPC5 inhibitor; also induces autophagy

Discontinued Product

6494 has been discontinued. View all TRPC Channel Blockers products.

Key Product Details

Description:	TRPC5 inhibitor; also induces autophagy
Chemical Name:	3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
Purity:	≥98% (HPLC)
Molecular Weight:	270.24

View Full Technical Details for Galangin

Technical Data
Citations

Biological Activity for Galangin

Galangin is a TRPC5 inhibitor. Inhibits Ca²⁺ entry into TRPC5 expressing cells. Inhibits LPS-induced expression of TNFα, IL-6, IL-1β, COX2 and iNOS, in vitro. Attenuates microglial activation, loss of dopaminergic neurons and motor dysfunction in a LPS-induced rat model of Parkinson's disease. Also inhibits proliferation in breast cancer cell lines. Induces autophagy. Also displays antiviral activity against HSV-1, coxsackie B virus type 1, adenovirus type 31 and reovirus.

Technical Data for Galangin

M. Wt	270.24
Formula	C₁₅H₁₀O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	548-83-4
PubChem ID	5281616
InChi Key	VCCRNZQBSJXYJD-UHFFFAOYSA-N
Smiles	OC1=CC(O)=C2C(OC(C3=CC=CC=C3)=C(C2=O)O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Galangin

References are publications that support the biological activity of the product.

Meyer Antiviral activity of galangin isolated from the aerial parts of Helichrysum aureonitens. J.Ethnopharmacol. 1997 PMID: 9174978
Wen Galangin induces autophagy through upregulation of p53 in HepG2 cells. Pharmacology. 2012 PMID: 22507894
Chen Galangin reduces the loss of DArgic neurons in an LPS-evoked model of Parkinson's disease in rats. Int.J.Mol.Sci. 2017 PMID: 29267220
So Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr.Cancer. 1996 PMID: 8875554
Naylor Natural and synthetic flavonoid modulation of TRPC5 channels. Br.J.Pharmacol. 2016 PMID: 26565375

Galangin

Tocris Bioscience, part of Bio-Techne | Catalog # 6494

Key Product Details

Biological Activity for Galangin

Technical Data for Galangin

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Galangin

Product Documents for Galangin

COA

Certificate of Analysis

SDS

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