Gabexate mesylate

Name: Gabexate mesylate
Brand: Tocris Bioscience
SKU: 1798

Tocris Bioscience, part of Bio-Techne | Catalog # 1798

Citations (2)

COA / SDS

Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin

Key Product Details

Description:	Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin
Alternative Names:	FOY
Chemical Name:	4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate
Purity:	≥98% (HPLC)
Molecular Weight:	417.48

View Full Technical Details for Gabexate mesylate

Technical Data
Citations

Biological Activity for Gabexate mesylate

Gabexate mesylate is a serine protease inhibitor; Gabexate mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC₅₀ values are 9.4, 30, 41 and 110 μM respectively). Antithrombotic in vitro and in vivo. Gabexate mesylate also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation. Gabexate mesylate attenuates allergen-induced airway inflammation and eosinophils infiltration in the lung of asthma murine model.

Technical Data for Gabexate mesylate

M. Wt	417.48
Formula	C₁₆H₂₃N₃O₄.CH₃SO₃H
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	56974-61-9
PubChem ID	6604915
InChi Key	ICDMLAQPOAVWNH-HAAQQRBASA-N
Smiles	CS(O)(=O)=O.CCOC(=O)C1=CC=C(OC(=O)CCCCCNC(N)=N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Gabexate mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	41.75	100

Preparing Stock Solutions for Gabexate mesylate

The following data is based on the product molecular weight 417.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.40 mL	11.98 mL	23.95 mL
5 mM	0.48 mL	2.40 mL	4.79 mL
10 mM	0.24 mL	1.20 mL	2.40 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for Gabexate mesylate

References are publications that support the biological activity of the product.

Chen Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen induced airway inflammation and eosinophilia in a murine model of asthma. J.Allergy Clin.Immunol. 2006 PMID: 16815145
Yuksel Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α production by inhibiting activation of both nuclear factor-κB and activator protein-1 in human monocytes. J.Pharmacol.Exp.Ther. 2003 PMID: 12649382
Ohno FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. II. In vivo effect on coagulo-fibrinolytic system in comparison with he. or apro. Thromb.Res. 1981 PMID: 6178174
Tamura Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C_1r and C₁ esterase. Biochim.Biophys.Acta 1977 PMID: 143965
Ohno FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro. Thromb.Res. 1980 PMID: 6449757