G-15
Tocris Bioscience, part of Bio-Techne | Catalog # 3678
High affinity and selective GPER antagonist
Key Product Details
Description
High affinity and selective GPER antagonist
Product Description
G-15 is a high affinity and selective GPER receptor antagonist (Ki = 20 nM) that displays no affinity for ERα and ERβ at concentrations up to 10 μM. Inhibits agonist-induced calcium mobilization in vitro (EC50 of ~185 nM) and antagonizes the antidepressive and renoprotective effects of estrogen in vivo.Product Specifications
Molecular Weight
370.24
Formula
C19H16BrNO2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline
CAS Number
1161002-05-6
PubChem ID
90488870
InChI Key
LBBDCJLRQXMUAE-FWHYVADDSA-N
SMILES
BrC1=CC4=C(OCO4)C=[C@@]1[C@@H]2NC(C=CC=C5)=C5[C@@]3([H])[C@@]([H])2CC=C3.BrC6=CC9=C(OCO9)C=[C@@]6[C@H]7NC(C=CC=C%10)=C%10[C@]8([H])[C@]([H])7CC=C8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.51 | 50 |
Preparing Stock Solutions
for G-15
The following data is based on the product molecular weight 370.24
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.40 mL | 27.01 mL | 54.02 mL |
| 2.5 mM | 1.08 mL | 5.40 mL | 10.80 mL |
| 5 mM | 0.54 mL | 2.70 mL | 5.40 mL |
| 25 mM | 0.11 mL | 0.54 mL | 1.08 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hutchens Estrogen protects renal endothelial barrier function from ischemia-reperfusion in vitro and in vivo. Am.J.Physiol.Renal Physiol. 2012 PMID: 22622457
- Yue Activation of G-protein-coupled receptor 30 protects neurons against excitotoxicity through inhibiting excessive autophagy induced by glutamate. ACS Chem.Neurosci. 2019 PMID: 31545891
- Dennis In vivo effects of a GPR30 antagonist. Nat.Chem.Biol. 2009 PMID: 19430488
Product Specific Notices for G-15
For research use only
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