FTI 277

Name: FTI 277
Brand: Tocris Bioscience
SKU: 2407

Tocris Bioscience, part of Bio-Techne | Catalog # 2407

Citations (5)

COA / SDS

Prodrug form of FTI 276 (Cat. No. 2406)

Discontinued Product

2407 has been discontinued. View all Other Transferase Inhibitors products.

Key Product Details

Description:	Prodrug form of FTI 276 (Cat. No. 2406)
Chemical Name:	N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt
Purity:	≥95% (HPLC)
Molecular Weight:	561.64

View Full Technical Details for FTI 277

Technical Data
Citations

Biological Activity for FTI 277

FTI 277 is a prodrug form of FTI 276 (Cat. No. 2406) that inhibits farnesyltransferase (FTase) (IC₅₀ = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC₅₀ values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.

Technical Data for FTI 277

M. Wt	561.64
Formula	C₂₂H₂₉N₃O₃S₂.C₂HF₃O₂
Storage	Store at -80°C
Purity	≥95% (HPLC)
CAS Number	1217447-06-7
PubChem ID	71311821
InChi Key	GJEFFRDWFVSCOJ-PXPMWPIZSA-N
Smiles	SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@@](OC)=O)CCSC)=O)C(C2=CC=CC=C2)=C1.FC(F)(C(O)=O)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for FTI 277

References are publications that support the biological activity of the product.

Sun Antitumour efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Tax. and gemcit. Cancer Res. 1999 PMID: 10519405
Lerner Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J.Biol.Chem.
Lerner Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling inducing cytoplasic accumulation of inactive Ras-Raf complexes. J.Biol.Chem. 1995 PMID: 7592920

FTI 277

Tocris Bioscience, part of Bio-Techne | Catalog # 2407

Key Product Details

Biological Activity for FTI 277

Technical Data for FTI 277

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for FTI 277

Product Documents for FTI 277

COA

Certificate of Analysis

SDS

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