FTBMT

Name: FTBMT
Brand: Tocris Bioscience
SKU: 6784

Tocris Bioscience, part of Bio-Techne | Catalog # 6784

COA / SDS

Potent and selective GPR52 agonist; orally bioavailable and BBB permeable

Key Product Details

Description:	Potent and selective GPR52 agonist; orally bioavailable and BBB permeable
Alternative Names:	TP-024
Chemical Name:	4-[3-[[3-Fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methylbenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	392.35

View Full Technical Details for FTBMT

Technical Data
Citations

Biological Activity for FTBMT

FTBMT (also known as TP 024) is a potent and selective GPR52 agonist (EC₅₀ = 75 nM, E_max = 122%), which is selective for GPR52 over a panel of 98 targets including D₁, D₂, AMPA and NMDA. FTBMT suppresses methamphetamine-induced hyperlocomotion in mice, and inhibits MK-801-induced hyperactivity (model for acute psychosis), without causing catalepsy in mice. This compound is orally bioavailable and brain penetrant.

Compound Libraries for FTBMT

FTBMT is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of FTBMT (TP 024) is reviewed on chemicalprobes.org and the SGC website.

Technical Data for FTBMT

M. Wt	392.35
Formula	C₁₉H₁₆F₄N₄O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1358575-02-6
PubChem ID	56649300
InChi Key	TYXSIXOYTBHZFA-UHFFFAOYSA-N
Smiles	CC1=NC(CC2=CC(C(F)(F)F)=CC(F)=C2)=NN1C3=CC(C)=C(C(N)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FTBMT

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.23	100
	ethanol	19.62	50

Preparing Stock Solutions for FTBMT

The following data is based on the product molecular weight 392.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.74 mL	25.49 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
10 mM	0.25 mL	1.27 mL	2.55 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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Reconstitution Calculator

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References for FTBMT

References are publications that support the biological activity of the product.

Nishiyama FTBMT, a novel and selective GPR52 agonist, demonstrates antipsychotic-like and procognitive effects in rodents, revealing a potential therapeutic agent for schizophrenia. J.Pharmacol.Exp.Ther. 2017 PMID: 28851764
Tokumaru Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg.Med.Chem. 2017 PMID: 28433511