FR 171113
Tocris Bioscience, part of Bio-Techne | Catalog # 3643
PAR1 antagonist
Product Description
FR 171113 is a protease-activated receptor 1 (PAR1) antagonist. Exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time.Product Specifications
Molecular Weight
469.73
Formula
C19H11Cl3N2O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester
CAS Number
173904-50-2
PubChem ID
25015749
InChI Key
SDGLYCKTPKZBGI-DALCUZTNSA-N
SMILES
O=C(/N=C(N(C3=CC=C(Cl)C=C3)C2=O)\S/C2=C/C(OC)=O)C1=CC=C(Cl)C=C1Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.7 | 10 |
Preparing Stock Solutions
for FR 171113
The following data is based on the product molecular weight 469.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.29 mL | 106.44 mL | 212.89 mL |
| 0.5 mM | 4.26 mL | 21.29 mL | 42.58 mL |
| 1 mM | 2.13 mL | 10.64 mL | 21.29 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kato Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig. Eur.J.Pharmacol. 2003 PMID: 12892834
- Kato In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist. Eur.J.Pharmacol. 1999 PMID: 10611442
Product Specific Notices for FR 171113
For research use only
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