FPA 124

Catalog # 2926 | Tocris Bioscience a Bio-Techne Brand

Akt/PKB inhibitor

Key Product Details

Description:	Akt/PKB inhibitor
Chemical Name:	Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide copper complex
Molecular Weight:	381.73

View Full Technical Details for FPA 124

Technical Data
Citations (1) / Reviews

Biological Activity for FPA 124

FPA 124 is an Akt/PKB inhibitor (IC₅₀ = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.

Technical Data for FPA 124

M. Wt	381.73
Formula	C₁₁H₉Cl₂CuN₃O₂S
Storage	Store at +4°C
CAS Number	902779-59-3
PubChem ID	16034833
InChi Key	HZRXQEVFXXQYFS-VBPDOGLUSA-L
Smiles	Cl[Cu]Cl.NC(=S)N\N=C\C1=COC2=C(C=CC=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for FPA 124

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	3.82	10
	ethanol	3.82	10

Preparing Stock Solutions for FPA 124

The following data is based on the product molecular weight 381.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.20 mL	130.98 mL	261.97 mL
0.5 mM	5.24 mL	26.20 mL	52.39 mL
1 mM	2.62 mL	13.10 mL	26.20 mL
5 mM	0.52 mL	2.62 mL	5.24 mL

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References for FPA 124

References are publications that support the biological activity of the product.

Barve Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J.Med.Chem. 2006 PMID: 16789737

Citations for FPA 124 (1)

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Citations are publications that use Bio-Techne products. Selected citations for FPA 124 include:

Liddell et al. (2016) Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation. 13:49
PMID: 26920699

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