Flufenamic acid

Name: Flufenamic acid
Brand: Tocris Bioscience
SKU: 4522
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4522

(1)

Citations (21)

COA / SDS

Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6

Key Product Details

Description:	Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6
Chemical Name:	2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	281.23

View Full Technical Details for Flufenamic acid

Technical Data
Citations / Reviews (1)

Biological Activity for Flufenamic acid

Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.

Technical Data for Flufenamic acid

M. Wt	281.23
Formula	C₁₄H₁₀F₃NO₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	530-78-9
PubChem ID	3371
InChi Key	LPEPZBJOKDYZAD-UHFFFAOYSA-N
Smiles	O=C(C1=C(NC2=CC=CC(C(F)(F)F)=C2)C=CC=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Flufenamic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.12	100
	ethanol	28.12	100

Preparing Stock Solutions for Flufenamic acid

The following data is based on the product molecular weight 281.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.56 mL	17.78 mL	35.56 mL
5 mM	0.71 mL	3.56 mL	7.11 mL
10 mM	0.36 mL	1.78 mL	3.56 mL
50 mM	0.07 mL	0.36 mL	0.71 mL

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Reconstitution Calculator

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References for Flufenamic acid

References are publications that support the biological activity of the product.

White and Aylwin Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes. Mol.Pharmacol. 1990 PMID: 1692608
Foster Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells. Cell Calcium 2009 PMID: 19232718
Chi Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase. J.Pharmacol.Exp.Ther. 2011 PMID: 21765041
Tu Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons. J.Neurochem. 2009 PMID: 19094061