FH 535

Name: FH 535
Brand: Tocris Bioscience
SKU: 4344

Tocris Bioscience, part of Bio-Techne | Catalog # 4344

Citations (22)

COA / SDS

Inhibitor of Wnt/β-catenin signaling

Discontinued Product

4344 has been discontinued. View all beta-Catenin Inhibitors products.

Key Product Details

Description:	Inhibitor of Wnt/β-catenin signaling
Chemical Name:	2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	361.2

View Full Technical Details for FH 535

Technical Data
Citations

Biological Activity for FH 535

FH 535 is an inhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.

Compound Libraries for FH 535

FH 535 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for FH 535

M. Wt	361.2
Formula	C₁₃H₁₀Cl₂N₂O₄S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	108409-83-2
PubChem ID	3463933
InChi Key	AXNUEXXEQGQWPA-UHFFFAOYSA-N
Smiles	ClC1=CC(S(NC2=C(C)C=C([N+]([O-])=O)C=C2)(=O)=O)=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for FH 535

References are publications that support the biological activity of the product.

Handeli and Simon A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities. Mol.Cancer Ther. 2008 PMID: 18347139