FG 7142
Tocris Bioscience, part of Bio-Techne | Catalog # 0554
Benzodiazepine inverse agonist
Key Product Details
Description
Benzodiazepine inverse agonist
Product Description
FG 7142 is a benzodiazepine inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β-adrenoceptors in mouse cerebral cortex.Product Specifications
Molecular Weight
225.25
Formula
C13H11N3O
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
N-Methyl-β-carboline-3-carboxamide
CAS Number
78538-74-6
PubChem ID
4375
InChI Key
QMCOPDWHWYSJSA-UHFFFAOYSA-N
SMILES
CNC(=O)C1=CC2=C(NC3=C2C=CC=C3)C=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 16.89 | 75 | |
| DMSO | 22.52 | 100 |
Preparing Stock Solutions
for FG 7142
The following data is based on the product molecular weight 225.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.44 mL | 22.20 mL | 44.40 mL |
| 5 mM | 0.89 mL | 4.44 mL | 8.88 mL |
| 10 mM | 0.44 mL | 2.22 mL | 4.44 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.89 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wettstei Behavioural studies with the β-carboline FG 7142 combined with related drugs in monkeys. Eur.J.Pharmacol. 1989 PMID: 2498110
- Knorr The anxiogenic β-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain Res. 1989 PMID: 2765936
- Stanford A single dose of FG 7142 causes long term increases in mouse cortical β-adrenoceptors. Eur.J.Pharmacol. 1987 PMID: 3032657
- Donner Evidence for an excitatory action of benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents. Naunyn Schmiedebergs Arch.Pharmacol. 1989 PMID: 2478895
Product Specific Notices for FG 7142
For research use only
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