Fenoldopam hydrochloride

Name: Fenoldopam hydrochloride
Brand: Tocris Bioscience
SKU: 1659

Tocris Bioscience, part of Bio-Techne | Catalog # 1659

Citations (9)

COA / SDS

Selective D1-like partial agonist

Key Product Details

Description:	Selective D₁-like partial agonist
Alternative Names:	SKF 82526
Chemical Name:	6-Chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	342.22

View Full Technical Details for Fenoldopam hydrochloride

Technical Data
Citations

Biological Activity for Fenoldopam hydrochloride

Fenoldopam hydrochloride is a selective D₁-like dopamine receptor partial agonist (EC₅₀ = 57 nM). Vasodilator in vivo and does not readily cross the blood-brain barrier. Also α₂-adrenoceptor antagonist in vitro (K_i = 15 - 25 nM).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for Fenoldopam hydrochloride

M. Wt	342.22
Formula	C₁₆H₁₆ClNO₃.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	181217-39-0
PubChem ID	21642479
InChi Key	NLMPGIXLXSPNFS-UHFFFAOYSA-N
Smiles	Cl.OC1=CC=C(C=C1)C1CNCCC2=C(Cl)C(O)=C(O)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Fenoldopam hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	3.06	10

Preparing Stock Solutions for Fenoldopam hydrochloride

The following data is based on the product molecular weight 342.22.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.22 mL	146.10 mL	292.21 mL
0.5 mM	5.84 mL	29.22 mL	58.44 mL
1 mM	2.92 mL	14.61 mL	29.22 mL
5 mM	0.58 mL	2.92 mL	5.84 mL

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References for Fenoldopam hydrochloride

References are publications that support the biological activity of the product.

Nichols The pharmacology of fenol. Am.J.Hypertens. 1990 PMID: 1974439
Sibley Interactions of novel DArgic ligands with D-1 and D-2 DA receptors. Life Sci. 1982 PMID: 6127585
Hahn Characterization of the peripheral and central effects of SK&F 82526, a novel DA receptor agonist. J.Pharmacol.Exp.Ther. 1982 PMID: 6127401