Exo1
Tocris Bioscience, part of Bio-Techne | Catalog # 1850
Inhibits Golgi-ER traffic; blocks exocytosis
Discontinued Product
1850 has been discontinued.
View all Translocation, Exo/Endocytosis Products products.
Key Product Details
Description
Inhibits Golgi-ER traffic; blocks exocytosis
Product Description
Exo1 is a reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Modifies Golgi ADP-ribosylation factor (ARF)1 GTPase activity and inhibits exocytosis (IC50 ~ 20 μM). Has similar, but not identical, action to brefeldin A (Cat. No. 1231).Product Specifications
Molecular Weight
273.26
Formula
C15H12FNO3
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
2-[(4-Fluorobenzoyl)amino]-benzoic acid methyl ester
CAS Number
461681-88-9
PubChem ID
310557
InChI Key
KIAPWMKFHIKQOZ-UHFFFAOYSA-N
SMILES
COC(=O)C1=CC=CC=C1NC(=O)C1=CC=C(F)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.33 | 100 | |
| Ethanol | 6.83 | 25 with gentle warming |
Preparing Stock Solutions
for Exo1
The following data is based on the product molecular weight 273.26
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.66 mL | 18.30 mL | 36.60 mL |
| 5 mM | 0.73 mL | 3.66 mL | 7.32 mL |
| 10 mM | 0.37 mL | 1.83 mL | 3.66 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Feng Exo1: A new chemical inhibitor of the exocytic pathway. Proc.Natl.Acad.Sci.U.S.A. 2003 PMID: 12738886
Product Specific Notices for Exo1
For research use only
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