Etomidate

Name: Etomidate
Brand: Tocris Bioscience
SKU: 1471
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1471

(1)

Citations (34)

COA / SDS

GABA-mimetic; selectively interacts with β2- and β3-subunit containing GABAA receptors

Key Product Details

Description:	GABA-mimetic; selectively interacts with β2- and β3-subunit containing GABA_A receptors
Chemical Name:	(R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	244.29

View Full Technical Details for Etomidate

Technical Data
Citations / Reviews (1)

Biological Activity for Etomidate

Etomidate is a general anesthetic with GABA modulatory and GABA-mimetic actions; selectively interacts with β2- and β3-subunit containing GABA_A receptors. Short acting and potent hypnotic, with low toxicity.

Technical Data for Etomidate

M. Wt	244.29
Formula	C₁₄H₁₆N₂O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	33125-97-2
PubChem ID	667484
InChi Key	NPUKDXXFDDZOKR-LLVKDONJSA-N
Smiles	O=C(OCC)C1=CN=CN1[C@@H]([C@@]2=CC=CC=C2)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Etomidate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	24.43	100
	1eq. HCl	12.21	50

Preparing Stock Solutions for Etomidate

The following data is based on the product molecular weight 244.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.09 mL	20.47 mL	40.93 mL
5 mM	0.82 mL	4.09 mL	8.19 mL
10 mM	0.41 mL	2.05 mL	4.09 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

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Reconstitution Calculator

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References for Etomidate

References are publications that support the biological activity of the product.

Giese EtoM.: a new intravenous anesthetic induction agent. Pharmacother. 1983 PMID: 6359080
Moody Distinct structural requirements for the direct and indirect actions of the anaesthetic EtoM. at GABA_A receptors. Toxicol.Lett. 1998 PMID: 10049144
Belelli The interaction of the general anesthetic EtoM. with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proc.Natl.Acad.Sci.U.S.A. 1997 PMID: 9380754