ER 27319 maleate

Name: ER 27319 maleate
Brand: Tocris Bioscience
SKU: 2471
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2471

(1)

Citations (5)

COA / SDS

Selective Syk kinase inhibitor

Key Product Details

Description:	Selective Syk kinase inhibitor
Chemical Name:	10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate
Purity:	≥98% (HPLC)
Molecular Weight:	396.17

View Full Technical Details for ER 27319 maleate

Technical Data
Citations / Reviews (1)

Biological Activity for ER 27319 maleate

ER 27319 maleate is a selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC₅₀ = 10 μM) and other related signaling events.

Compound Libraries for ER 27319 maleate

ER 27319 maleate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for ER 27319 maleate

M. Wt	396.17
Formula	C₁₈H₂₀N₂O.C₄H₄O₄
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	1204480-26-1
PubChem ID	56972172
InChi Key	WVUQPGFRFBVJKH-BTJKTKAUSA-N
Smiles	OC(=O)\C=C/C(O)=O.CC1=C(C)C2=C(C=C1)C(=O)C1=CC=CC=C1N2CCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ER 27319 maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	29.71	75
	DMSO	39.62	100

Preparing Stock Solutions for ER 27319 maleate

The following data is based on the product molecular weight 396.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.62 mL	25.24 mL
5 mM	0.50 mL	2.52 mL	5.05 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for ER 27319 maleate

References are publications that support the biological activity of the product.

Moriya ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk. Proc.Natl.Acad.Sci.USA
Luskova and Draber Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr.Pharm.Des. 2004 PMID: 15180535