Eplerenone
Tocris Bioscience, part of Bio-Techne | Catalog # 2397
Selective mineralocorticoid receptor antagonist
Key Product Details
Description
Selective mineralocorticoid receptor antagonist
Alternative Names
Inspra,Epoxymexrenone
Product Description
Eplerenone is a selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.Product Specifications
Molecular Weight
414.50
Formula
C24H30O6
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
CAS Number
107724-20-9
PubChem ID
443872
InChI Key
JUKPWJGBANNWMW-VWBFHTRKSA-N
SMILES
O=C1CC[C@@]2(C)C(C[C@@H]([C@](OC)=O)[C@]3([H])[C@@](O6)2[C@H]6C[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.14 | 10 |
Preparing Stock Solutions
for Eplerenone
The following data is based on the product molecular weight 414.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.13 mL | 120.63 mL | 241.25 mL |
| 0.5 mM | 4.83 mL | 24.13 mL | 48.25 mL |
| 1 mM | 2.41 mL | 12.06 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- McMahon and Cunningham Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 2001 PMID: 11714095
- De Gasparo Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 1987 PMID: 2949071
Product Specific Notices for Eplerenone
For research use only
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