Endoxifen

Name: Endoxifen
Brand: Tocris Bioscience
SKU: 3705

Tocris Bioscience, part of Bio-Techne | Catalog # 3705

Citations (7)

COA / SDS

Potent antiestrogen; ERα ligand

Discontinued Product

3705 has been discontinued. View all Additional Estrogen and Related Receptor Compounds products.

Key Product Details

Description:	Potent antiestrogen; ERα ligand
Chemical Name:	(E/Z)-4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol
Purity:	≥98% (HPLC)
Molecular Weight:	373.49

View Full Technical Details for Endoxifen

Technical Data
Citations

Biological Activity for Endoxifen

Endoxifen is an estrogen receptor α (ERα) ligand; potent antiestrogen. Metabolite of tamoxifen (Cat. No. 0999). Primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.

Technical Data for Endoxifen

M. Wt	373.49
Formula	C₂₅H₂₇NO₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	110025-28-0
PubChem ID	130621
InChi Key	MHJBZVSGOZTKRH-IZHYLOQSSA-N
Smiles	CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC)C=C2)\C3=CC=C(O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Endoxifen

References are publications that support the biological activity of the product.

Wu The tamox. metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor a for degradation in breast cancer cells. Cancer Res. 2009 PMID: 19244106
Wu Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen. Breast Cancer Res. 2011 PMID: 21392396
Lim Endoxifen, a secondary metabolite of tamoxifen, and 4-OH-tamoxifen induce similar changes in global gene expression patterns in MCF-7 breast cancer cells. J.Pharmacol.Exp.Ther. 2006 PMID: 16690721

Endoxifen

Tocris Bioscience, part of Bio-Techne | Catalog # 3705

Key Product Details

Biological Activity for Endoxifen

Technical Data for Endoxifen

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Endoxifen

Product Documents for Endoxifen

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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