Endothelin 2 (human)

Name: Endothelin 2 (human)
Brand: Tocris Bioscience
SKU: 1164

Tocris Bioscience, part of Bio-Techne | Catalog # 1164

Citations (4)

COA / SDS

ETA/ETB agonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

ETA/ETB agonist

Alternative Names

ET-2

View all Non-selective Endothelin Receptor Agonists »

Product Description

Endothelin 2 (human) is an endogenous peptide found predominately in the kidney and intestine. Displays similar selectivity for ET_A and ET_B endothelin receptors.

Product Specifications

Molecular Weight

2547.00

Formula

C₁₁₅H₁₆₀O₃₂N₂₆S₄

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

123562-20-9

PubChem ID

16133808

InChI Key

MLFJHYIHIKEBTQ-IYRKOGFYSA-N

SMILES

[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC3=C1C=CC=C3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in DMSO

Calculators

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Calculate the mass, volume, or concentration required for a solution.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Servitja Involvement of ET_A and ET_B receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes. Br.J.Pharmacol. 1998 PMID: 9756390
Yanagisawa and Masaski Molecular biology and biochemistry of the endothelins. TiPS 1989 PMID: 2690429
Inoue The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc.Natl.Acad.Sci.U.S.A. 1989 PMID: 2649896