Endothelin 2 (human)

Name: Endothelin 2 (human)
Brand: Tocris Bioscience
SKU: 1164

Tocris Bioscience, part of Bio-Techne | Catalog # 1164

Citations (4)

COA / SDS

ETA/ETB agonist

Key Product Details

Description:	ET_A/ET_B agonist
Alternative Names:	ET-2
Purity:	≥95% (HPLC)
Molecular Weight:	2547

View Full Technical Details for Endothelin 2 (human)

Technical Data
Citations

Biological Activity for Endothelin 2 (human)

Endothelin 2 (human) is an endogenous peptide found predominately in the kidney and intestine. Displays similar selectivity for ET_A and ET_B endothelin receptors.

Technical Data for Endothelin 2 (human)

M. Wt	2547
Formula	C₁₁₅H₁₆₀O₃₂N₂₆S₄
Single Letter Sequence	CSCSSWLDKECVYFCHLDIIW (Modifications: Disulfide bridges: 1-15, 3-11)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	123562-20-9
PubChem ID	16133808
InChi Key	MLFJHYIHIKEBTQ-IYRKOGFYSA-N
Smiles	[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC3=C1C=CC=C3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Endothelin 2 (human)

Solubility

Soluble to 1mg/ml in DMSO

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References for Endothelin 2 (human)

References are publications that support the biological activity of the product.

Servitja Involvement of ET_A and ET_B receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes. Br.J.Pharmacol. 1998 PMID: 9756390
Yanagisawa and Masaski Molecular biology and biochemistry of the endothelins. TiPS 1989 PMID: 2690429
Inoue The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc.Natl.Acad.Sci.U.S.A. 1989 PMID: 2649896