EMD 386088 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2382
Potent 5-HT6 agonist
Product Description
EMD 386088 hydrochloride is a potent 5-HT6 receptor agonist (EC50 = 1.0 nM) that displays selectivity over other 5-HT receptors (IC50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM).Product Specifications
Molecular Weight
283.20
Formula
C14H15N2Cl.HCl
Storage
Desiccate at RT
Purity
≥99% (HPLC)
Chemical Name
5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hydrochloride
CAS Number
1171123-46-8
PubChem ID
56972198
InChI Key
WWSNDUWIZDYGIQ-UHFFFAOYSA-N
SMILES
Cl.CC1=C(C2=CC(Cl)=CC=C2N1)C1=CCNCC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.08 | 25 | |
| DMSO | 28.32 | 100 |
Preparing Stock Solutions
for EMD 386088 hydrochloride
The following data is based on the product molecular weight 283.20
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.53 mL | 17.66 mL | 35.31 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.53 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mattsson 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg.Med.Chem.Lett. 2005 PMID: 16055331
Product Specific Notices for EMD 386088 hydrochloride
For research use only
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