EM 163
Tocris Bioscience, part of Bio-Techne | Catalog # 7010
TIR-TIR interaction inhibitor
Key Product Details
Description
TIR-TIR interaction inhibitor
Product Description
EM 163 is a TIR-TIR interaction inhibitor, that is a TIR (Toll/ interleukin-1 receptor) domain peptidomimetic of MyD88 protein. EM 163 targets TIR domains in IL-1 receptors blocking the interaction with MyD88. EM 163 inhibits staphylococcal enterotoxin B (SEB)-induced inflammatory cytokine production in vivo. EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocks the activation of p38 and the inhibitory effects of IL-1β on protein synthesis triggered by chemically-induced long-term potentiation (LTP).Product Specifications
Molecular Weight
849.90
Formula
C44H60IN5O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
1-Methyl-2,5-bis[[[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl](3-phenylpropyl)amino]carbonyl]pyridinium iodide
CAS Number
1206480-93-4
PubChem ID
44602511
InChI Key
WJCJDZIXEVJIKZ-OFUZFLEOSA-M
SMILES
CC([C@@H](C(N1CCCC1)=O)N(C(C2=C[N+](C)=C(C(N([C@H](C(N3CCCC3)=O)C(C)C)CCCC4=CC=CC=C4)=O)C=C2)=O)CCCC5=CC=CC=C5)C.[I-]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 84.99 | 100 |
Preparing Stock Solutions
for EM 163
The following data is based on the product molecular weight 849.90
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.18 mL | 5.88 mL | 11.77 mL |
| 5 mM | 0.24 mL | 1.18 mL | 2.35 mL |
| 10 mM | 0.12 mL | 0.59 mL | 1.18 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.24 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kissner Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88. PLoS One 2012 PMID: 22848400
- Lucas and Maes Role of the toll like receptor (TLR) radical cycle in chronic inflammation: possible treatments targeting the TLR4 pathway. Mol.Neurobiol. 2013 PMID: 23436141
- Prieto Inhibition of LTP-induced translation by IL-1β reduces the level of newly synthesized proteins in hippocampal dendrites. ACS Chem.Neurosci. 2019 PMID: 30695637
Product Specific Notices for EM 163
For research use only
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