Efonidipine hydrochloride monoethanolate

Name: Efonidipine hydrochloride monoethanolate
Brand: Tocris Bioscience
SKU: 3733

Tocris Bioscience, part of Bio-Techne | Catalog # 3733

COA / SDS

CaV1.x and CaV3.x blocker

Discontinued Product

3733 has been discontinued. View all Cav1.x Channel Blockers products.

Key Product Details

Description:	Ca_V1.x and Ca_V3.x blocker
Chemical Name:	5-(5,5-Dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid 2-[phenyl(phenylmethyl)amino]ethyl ester hydrochloride monoethanolate
Purity:	≥99% (HPLC)
Molecular Weight:	714.18

View Full Technical Details for Efonidipine hydrochloride monoethanolate

Technical Data
Citations

Biological Activity for Efonidipine hydrochloride monoethanolate

Selective blocker of L-type and T-type Ca²⁺ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R(-) and S(+)-enantiomers display different channel selectivity; S(+)-Efonidipine blocks L-type and T-type channels whereas R(-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.

Technical Data for Efonidipine hydrochloride monoethanolate

M. Wt	714.18
Formula	C₃₄H₃₈N₃O₇P.HCl.C₂H₅OH
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	111011-76-8
PubChem ID	163838
InChi Key	IKBJGZQVVVXCEQ-UHFFFAOYSA-N
Smiles	CC1=C(P4(OCC(C)(C)CO4)=O)C(C3=CC([N+]([O-])=O)=CC=C3)C(C(OCCN(CC5=CC=CC=C5)C2=CC=CC=C2)=O)=C(C)N1.CCO.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Efonidipine hydrochloride monoethanolate

References are publications that support the biological activity of the product.

Furukawa Identification of R(-)-isomer of efonidipine as a selective blocker of T-type Ca²⁺ channels. Br.J.Pharmacol. 2004 PMID: 15545287
Shin A selective T-type Ca²⁺ channel blocker R(-) efonidipine. Naunyn-Schmied.Arch.Pharmacol.
Masumiya Inhibition of myocardial L- and T-type Ca²⁺ currents by efonidipine: possible mechanism for its chronotropic effect. Eur.J.Pharmacol. 1998 PMID: 9671117

Efonidipine hydrochloride monoethanolate

Tocris Bioscience, part of Bio-Techne | Catalog # 3733

Key Product Details

Biological Activity for Efonidipine hydrochloride monoethanolate

Technical Data for Efonidipine hydrochloride monoethanolate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Efonidipine hydrochloride monoethanolate

Product Documents for Efonidipine hydrochloride monoethanolate

COA

Certificate of Analysis

SDS

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