Ebio1

Name: Ebio1
Brand: Tocris Bioscience
SKU: 8137

Tocris Bioscience, part of Bio-Techne | Catalog # 8137

COA / SDS

KCNQ2 activator

Key Product Details

Description:	KCNQ2 activator
Chemical Name:	N-(1,2-Dihydro-5-acenaphthylenyl)-4-fluorobenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	291.33

View Full Technical Details for Ebio1

Technical Data
Citations

Biological Activity for Ebio1

Ebio1 is an activator of KCNQ2 voltage-gated potassium channels (EC₅₀ = 247 nM). Ebio1 activates KCNQ2 by increasing both the open probability and the conductance of the channel. Ebio1 has no effect on the voltage sensitivity of KCNQ1, KCNQ3, KCNQ4 and KCNQ5.

Technical Data for Ebio1

M. Wt	291.33
Formula	C₁₉H₁₄FNO
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	339287-36-4
PubChem ID	759702
InChi Key	VROYHHCUXRMIQY-UHFFFAOYSA-N
Smiles	O=C(C1=CC=C(C=C1)F)NC2=CC=C3C4=C(CC3)C=CC=C42

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ebio1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.13	100
	ethanol	5.83	20

Preparing Stock Solutions for Ebio1

The following data is based on the product molecular weight 291.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.43 mL	17.16 mL	34.33 mL
5 mM	0.69 mL	3.43 mL	6.87 mL
10 mM	0.34 mL	1.72 mL	3.43 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

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Reconstitution Calculator

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References for Ebio1

References are publications that support the biological activity of the product.

Zhang A small-molecule activation mechanism that directly opens the KCNQ2 channel. Nat.Chem.Biol. 2024 PMID: 38167918