Ebio1
Tocris Bioscience, part of Bio-Techne | Catalog # 8137
KCNQ2 activator
Key Product Details
Description
KCNQ2 activator
Product Description
Ebio1 is an activator of KCNQ2 voltage-gated potassium channels (EC50 = 247 nM). Ebio1 activates KCNQ2 by increasing both the open probability and the conductance of the channel. Ebio1 has no effect on the voltage sensitivity of KCNQ1, KCNQ3, KCNQ4 and KCNQ5.Product Specifications
Molecular Weight
291.33
Formula
C19H14FNO
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(1,2-Dihydro-5-acenaphthylenyl)-4-fluorobenzamide
CAS Number
339287-36-4
PubChem ID
759702
InChI Key
VROYHHCUXRMIQY-UHFFFAOYSA-N
SMILES
O=C(C1=CC=C(C=C1)F)NC2=CC=C3C4=C(CC3)C=CC=C42
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.13 | 100 | |
| Ethanol | 5.83 | 20 |
Preparing Stock Solutions
for Ebio1
The following data is based on the product molecular weight 291.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.43 mL | 17.16 mL | 34.33 mL |
| 5 mM | 0.69 mL | 3.43 mL | 6.87 mL |
| 10 mM | 0.34 mL | 1.72 mL | 3.43 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.69 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang A small-molecule activation mechanism that directly opens the KCNQ2 channel. Nat.Chem.Biol. 2024 PMID: 38167918
Product Specific Notices for Ebio1
For research use only
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