EB 47
Tocris Bioscience, part of Bio-Techne | Catalog # 4140
Potent PARP-1 inhibitor
Key Product Details
Description
Potent PARP-1 inhibitor
Product Description
EB 47 is a potent inhibitor of PARP-1 (IC50 = 45 nM). Reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model.Product Specifications
Molecular Weight
610.45
Formula
C24H27N9O6.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride
CAS Number
1190332-25-2
PubChem ID
90488915
InChI Key
VVMQSDIMNDTMII-MYXHFVDASA-N
SMILES
NC1=C2N=CN([C@@H]3O[C@@H]([C@@H](O)[C@H]3O)C(N4CCN(CC(NC5=C6CNC(C6=CC=C5)=O)=O)CC4)=O)C2=NC=N1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.05 | 5 with gentle warming | |
| DMSO | 30.52 | 50 |
Preparing Stock Solutions
for EB 47
The following data is based on the product molecular weight 610.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.28 mL | 16.38 mL | 32.76 mL |
| 2.5 mM | 0.66 mL | 3.28 mL | 6.55 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.28 mL |
| 25 mM | 0.07 mL | 0.33 mL | 0.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ferraris Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic. J.Med.Chem. 2010 PMID: 20364863
- Gaymes Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica 2009 PMID: 19407318
- Jagtap The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1). Bioorg.Med.Chem.Lett. 2004 PMID: 14684303
Product Specific Notices for EB 47
For research use only
Loading...
Loading...
Loading...