E 2012

Name: E 2012
Brand: Tocris Bioscience
SKU: 5550

Tocris Bioscience, part of Bio-Techne | Catalog # 5550

Citations (4)

COA / SDS

γ-secretase modulator; Notch-sparing

Key Product Details

Description:	γ-secretase modulator; Notch-sparing
Chemical Name:	(3E)-1-[(1S)-1-(4-Fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylene]-2-piperidone
Purity:	≥98% (HPLC)
Molecular Weight:	419.49

View Full Technical Details for E 2012

Technical Data
Citations

Biological Activity for E 2012

E 2012 is a γ-secretase modulator. Lowers Aβ40 and Aβ42 levels and increases Aβ37 levels, in vitro and in vivo. Displays no effect on γ-secretase processing of Notch, EphA4 and EphB2.

Compound Libraries for E 2012

E 2012 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for E 2012

M. Wt	419.49
Formula	C₂₅H₂₆FN₃O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	870843-42-8
PubChem ID	11560787
InChi Key	PUOAETJYKQITMO-LANLRWRYSA-N
Smiles	COC1=C(N2C=C(C)N=C2)C=CC(/C=C3CCCN([C@@H](C)C4=CC=C(F)C=C4)C\3=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for E 2012

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	41.95	100
	DMSO	41.95	100

Preparing Stock Solutions for E 2012

The following data is based on the product molecular weight 419.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.92 mL	23.84 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for E 2012

References are publications that support the biological activity of the product.

Portelius Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs. J.Alzheimers Dis. 2010 PMID: 20634579
Borgegard First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms. J.Biol.Chem. 2012 PMID: 22334705