DY131

Name: DY131
Brand: Tocris Bioscience
SKU: 2266

Tocris Bioscience, part of Bio-Techne | Catalog # 2266

Citations (31)

COA / SDS

Agonist selective for estrogen-related receptors ERRβ and ERRγ

Key Product Details

Description:	Agonist selective for estrogen-related receptors ERRβ and ERRγ
Chemical Name:	N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine
Purity:	≥98% (HPLC)
Molecular Weight:	311.38

View Full Technical Details for DY131

Technical Data
Citations

Biological Activity for DY131

DY131 is a selective agonist at estrogen-related receptors ERRβ (EC₅₀ range = 130 - 698 nM in vitro) and ERRγ. Displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. In a mouse model of hepatotoxicity, DY131 protects against LPS induced liver injury. Suppresses growth and proliferation of prostate, esophagus, gastric and breast cancer cells; concentration-dependently increases cell proliferation in T98G and U87MG cells (EC₅₀ values are 54 nM and 62 nM respectively).

Compound Libraries for DY131

DY131 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DY131

M. Wt	311.38
Formula	C₁₈H₂₁N₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	95167-41-2
PubChem ID	5497124
InChi Key	WLKOCYWYAWBGKY-CPNJWEJPSA-N
Smiles	CCN(CC)C1=CC=C(C=C1)\C=N\NC(=O)C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DY131

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	3.11	10
	DMSO	31.14	100

Preparing Stock Solutions for DY131

The following data is based on the product molecular weight 311.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.21 mL	16.06 mL	32.12 mL
5 mM	0.64 mL	3.21 mL	6.42 mL
10 mM	0.32 mL	1.61 mL	3.21 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for DY131

References are publications that support the biological activity of the product.

Ma Estrogen-related receptor γ agonist DY131 ameliorates lipopolysaccharide-induced acute liver injury. Front.Pharmacol. 2021 PMID: 33967760
Wang ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy. J.Transl.Med. 2023 PMID: 37679788
Zuercher Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J.Med.Chem. 2005 PMID: 15857113
Heckler Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer. Oncotarget. 2016 PMID: 27363015
Gandhari Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells. Mol.Cell Endocrinol. 2010 PMID: 19822186
Thouennon Insights into the activation mechanism of human estrogen-related receptor γ by environmental endocrine disruptors. Cell Mol.Life Sci. 2019 PMID: 31127318
Yu and Forman Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorg.Med.Chem.Lett. 2005 PMID: 15713377