DY131

Product Description

DY131 is a selective agonist at estrogen-related receptors ERRβ (EC₅₀ range = 130 - 698 nM in vitro) and ERRγ. Displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. In a mouse model of hepatotoxicity, DY131 protects against LPS induced liver injury. Suppresses growth and proliferation of prostate, esophagus, gastric and breast cancer cells; concentration-dependently increases cell proliferation in T98G and U87MG cells (EC₅₀ values are 54 nM and 62 nM respectively).

Solubility

Preparing Stock Solutions for DY131

The following data is based on the product molecular weight 311.38

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.21 mL	16.06 mL	32.12 mL
5 mM	0.64 mL	3.21 mL	6.42 mL
10 mM	0.32 mL	1.61 mL	3.21 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ma Estrogen-related receptor γ agonist DY131 ameliorates lipopolysaccharide-induced acute liver injury. Front.Pharmacol. 2021 PMID: 33967760
• Wang ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy. J.Transl.Med. 2023 PMID: 37679788
• Zuercher Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J.Med.Chem. 2005 PMID: 15857113
• Heckler Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer. Oncotarget. 2016 PMID: 27363015
• Gandhari Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells. Mol.Cell Endocrinol. 2010 PMID: 19822186
• Thouennon Insights into the activation mechanism of human estrogen-related receptor γ by environmental endocrine disruptors. Cell Mol.Life Sci. 2019 PMID: 31127318
• Yu and Forman Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorg.Med.Chem.Lett. 2005 PMID: 15713377