DY 268
Tocris Bioscience, part of Bio-Techne | Catalog # 5656
Potent FXR antagonist
Product Description
DY 268 is a potent FXR antagonist (IC50 = 7.5 nM). Exhibits no detectable cytotoxicity in cell-based assays.Licensing Information
Sold under license from the Beckman Research Institute of the City of Hope.Product Specifications
Molecular Weight
560.66
Formula
C30H32N4O5S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-[(3-Methoxyphenyl)methyl]-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxamide
CAS Number
1609564-75-1
PubChem ID
90656831
InChI Key
KQSPAAPFKIEUGH-UHFFFAOYSA-N
SMILES
CC1=C(S(N2CCOCC2)(=O)=O)C=C(NC(C3=CN(CC4=CC(OC)=CC=C4)N=C3C5=CC=C(C)C=C5)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.07 | 100 |
Preparing Stock Solutions
for DY 268
The following data is based on the product molecular weight 560.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.78 mL | 8.92 mL | 17.84 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.57 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.78 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yu Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg.Med.Chem. 2014 PMID: 24775917
Product Specific Notices for DY 268
For research use only
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