DSRM-3716

Product Description

DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC₅₀ = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters. In vitro, DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone (Cat. No. 3616)-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.

Solubility

Preparing Stock Solutions for DSRM-3716

The following data is based on the product molecular weight 255.06

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.92 mL	19.60 mL	39.21 mL
5 mM	0.78 mL	3.92 mL	7.84 mL
10 mM	0.39 mL	1.96 mL	3.92 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• O Hughes Small molecules SARM1 inhibitors recapitulate the SARM1-/- phenotype and allow recovery of a metastable pool of axons fated to degenerate. Cell Rep. 2021 PMID: 33406435