DSR 6434
Tocris Bioscience, part of Bio-Techne | Catalog # 4809
Potent TLR7 agonist
Product Description
DSR 6434 is a potent TLR7 agonist (EC50 = 7.2 nM). Activates several immune effector cells in vitro. Suppresses metastasis in vivo and enhances efficacy of radiation therapy in a model of colorectal carcinoma.Product Specifications
Molecular Weight
400.48
Formula
C19H28N8O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
6-Amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]-3-pyridinyl]methyl]-7,9-dihydro-8H-purin-8-one
CAS Number
1059070-10-8
PubChem ID
25071151
InChI Key
SSZHESNDOMBSRV-UHFFFAOYSA-N
SMILES
O=C2N(CC3=CC=C(OCCN(C)C)N=C3)C1=NC(NCCCC)=NC(N)=C1N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 20.02 | 50 | |
| DMSO | 40.05 | 100 |
Preparing Stock Solutions
for DSR 6434
The following data is based on the product molecular weight 400.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.49 mL | 24.97 mL |
| 5 mM | 0.50 mL | 2.50 mL | 4.99 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nakamura Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg.Med.Chem.Lett. 2013 PMID: 23265901
- Adlard A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int.J.Cancer 2014 PMID: 24390981
Product Specific Notices for DSR 6434
For research use only
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