DSP-4

Name: DSP-4
Brand: Tocris Bioscience
SKU: 2958

Tocris Bioscience, part of Bio-Techne | Catalog # 2958

Citations (20)

COA / SDS

Adrenergic neurotoxin

Key Product Details

Description:	Adrenergic neurotoxin
Chemical Name:	N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	313.06

View Full Technical Details for DSP-4

Technical Data
Citations

Biological Activity for DSP-4

DSP-4 is an adrenergic neurotoxin. Displays neurotoxic effects on both peripheral and central noradrenergic neurons.

Technical Data for DSP-4

M. Wt	313.06
Formula	C₁₁H₁₅BrClN.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	40616-75-9
PubChem ID	38533
InChi Key	NDDRNRRNYOULND-UHFFFAOYSA-N
Smiles	BrC1=CC=CC=C1CN(CC)CCCl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DSP-4

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	31.31	100
	ethanol	31.31	100

Preparing Stock Solutions for DSP-4

The following data is based on the product molecular weight 313.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.19 mL	15.97 mL	31.94 mL
5 mM	0.64 mL	3.19 mL	6.39 mL
10 mM	0.32 mL	1.60 mL	3.19 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for DSP-4

References are publications that support the biological activity of the product.

Kawamura Short and long term analysis of heart rate variations in spontaneous hypertensive rats: effect of DSP-4 administration. Biomed.Pharmacother. 2005 PMID: 16275495
Haidkind Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 [N(2-chloroethyl)-N-ethyl-2-bromobenzylamine] reduces DA release potential in the nucleus accumbens shell in conscious rats. Neurosci.Letts.
Jaim-Etcheverry and Zieher DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 1980 PMID: 7370771