DPTN

Name: DPTN
Brand: Tocris Bioscience
SKU: 7628

Tocris Bioscience, part of Bio-Techne | Catalog # 7628

COA / SDS

Potent and selective A3 adenosine receptor antagonist

Key Product Details

Description:	Potent and selective A₃ adenosine receptor antagonist
Chemical Name:	N-[4-(3,5-Dimethylphenyl)-5-(4-pyridinyl)-2-thiazolyl]-3-pyridinecarboxamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	459.39

View Full Technical Details for DPTN

Technical Data
Citations

Biological Activity for DPTN

DPTN is a potent and selective A₃ adenosine receptor antagonist (K_i values are in the range 0.36 - 1.65 nM (hA₃AR) and 1.6 - 8.53 nM (rA₃AR)). Reduces intrapulmonary pressure when combined with Dexamethasone (Cat. No. 1126). Readily crosses the blood brain barrier in rats.

Technical Data for DPTN

M. Wt	459.39
Formula	C₂₂H₁₈N₄OS.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	325767-87-1
InChi Key	GTWKWBXTCBUKTR-UHFFFAOYSA-N
Smiles	CC1=CC(C2=C(C3=CC=NC=C3)SC(NC(C4=CN=CC=C4)=O)=N2)=CC(C)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DPTN

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.19	20 with gentle warming

Preparing Stock Solutions for DPTN

The following data is based on the product molecular weight 459.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.88 mL	54.42 mL	108.84 mL
1 mM	2.18 mL	10.88 mL	21.77 mL
2 mM	1.09 mL	5.44 mL	10.88 mL
10 mM	0.22 mL	1.09 mL	2.18 mL

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References for DPTN

References are publications that support the biological activity of the product.

Suresh Selective A3 adenosine receptor antagonist radioligand for human and rodent species. ACS Med.Chem.Lett. 2022 PMID: 35450351
Gao Pharmacological characterization of DPTN and other selective A₃ adenosine receptor antagonists. Purinergic Signal. 2021 PMID: 34713378