Dolastatin 10 trifluoroacetate

Name: Dolastatin 10 trifluoroacetate
Brand: Tocris Bioscience
SKU: 3375

Tocris Bioscience, part of Bio-Techne | Catalog # 3375

COA / SDS

Tubulin polymerization inhibitor

Discontinued Product

3375 has been discontinued. View all Microtubule Binding Compounds products.

Key Product Details

Description:	Tubulin polymerization inhibitor
Chemical Name:	N,N-Dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazol)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl--valinamide trifluoroacetate
Purity:	≥95% (HPLC)
Molecular Weight:	899.11

View Full Technical Details for Dolastatin 10 trifluoroacetate

Technical Data
Citations

Biological Activity for Dolastatin 10 trifluoroacetate

Dolastatin 10 trifluoroacetate is a tubulin polymerization inhibitor. Noncompetitively inhibits binding of radiolabeled vincristine to tubulin (K_i = 1.4 μM) and induces tubulin aggregation in vitro.

Technical Data for Dolastatin 10 trifluoroacetate

M. Wt	899.11
Formula	C₄₂H₆₈N₆O₆S.CF₃CO₂H
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2342568-65-2
PubChem ID	9810929
InChi Key	OFDNQWIFNXBECV-VFSYNPLYSA-N
Smiles	O=C(C[C@@H](OC)[C@@H](N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)[C@@H](C)CC)N1[C@@]([C@H](OC)[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C2=NC=CS2)=O)([H])CCC1.FC(C(O)=O)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Dolastatin 10 trifluoroacetate

References are publications that support the biological activity of the product.

Bai Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. Mol.Pharmacol. 1995 PMID: 7746283
Bai Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J.Biol.Chem. 1990 PMID: 2211617

Dolastatin 10 trifluoroacetate

Tocris Bioscience, part of Bio-Techne | Catalog # 3375

Key Product Details

Biological Activity for Dolastatin 10 trifluoroacetate

Technical Data for Dolastatin 10 trifluoroacetate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Dolastatin 10 trifluoroacetate

Product Documents for Dolastatin 10 trifluoroacetate

COA

Certificate of Analysis

SDS

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