DMF

Name: DMF
Brand: Tocris Bioscience
SKU: 4512
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4512

COA / SDS

Nrf2 pathway activator; neuroprotective

Discontinued Product

4512 has been discontinued. View all Additional Antioxidant Compounds products.

Key Product Details

Description:	Nrf2 pathway activator; neuroprotective
Alternative Names:	Dimethyl fumarate
Chemical Name:	2(E)-Butenedioic acid 1,4-dimethyl ester
Purity:	≥99%
Molecular Weight:	144.13

View Full Technical Details for DMF

Technical Data
Citations

Biological Activity for DMF

DMF is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. Displays cytoprotective effects in human spinal cord astrocytes, oligodendrocyte precursor cells and hippocampal neurons following hydrogen peroxide challenge. Exerts neuroprotective effects in vivo in experimental autoimmune encephalomyelitis. Primary metabolite (MMF, Cat. No. 4511) available.

Technical Data for DMF

M. Wt	144.13
Formula	C₆H₈O₄
Storage	Store at RT
Purity	≥99%
CAS Number	624-49-7
PubChem ID	637568
InChi Key	LDCRTTXIJACKKU-ONEGZZNKSA-N
Smiles	O=C(/C=C/C(OC)=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for DMF

References are publications that support the biological activity of the product.

Linker Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 2011 PMID: 21354971
Scannevin Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroid-derived)-like 2 pathway. J.Pharmacol.Exp.Ther. 2012 PMID: 22267202

DMF

Tocris Bioscience, part of Bio-Techne | Catalog # 4512

Key Product Details

Biological Activity for DMF

Technical Data for DMF

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for DMF

Product Documents for DMF

COA

Certificate of Analysis

SDS

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