(±)-PPCC oxalate

Name: (±)-PPCC oxalate
Brand: Tocris Bioscience
SKU: 3870

Catalog # 3870 | Tocris Bioscience a Bio-Techne Brand

Citations (6)

COA / SDS

Selective sigma (σ) agonist (σ1> σ2)

Key Product Details

Description:	Selective sigma (σ) agonist (σ₁> σ₂)
Chemical Name:	(1R,2S)-rel-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylic acid methyl ester oxalate
Purity:	≥99% (HPLC)
Molecular Weight:	469.53

View Full Technical Details for (±)-PPCC oxalate

Technical Data
Citations (6) / Reviews

Biological Activity for (±)-PPCC oxalate

(±)-PPCC oxalate is a selective sigma (σ) receptor ligand. Displays high affinity for σ₁; also binds at σ₂ sites (K_i = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT.

Compound Libraries for (±)-PPCC oxalate

(±)-PPCC oxalate is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for (±)-PPCC oxalate

M. Wt	469.53
Formula	C₂₄H₂₉NO₃.C₂H₂O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1781628-91-8
PubChem ID	90488889
InChi Key	IGJDSEGFEVKASG-KLELIYFTSA-N
Smiles	CC(C=C3)=CC=C3[C@@]1(C(OC)=O)C[C@@H]1CN2CCC(C4=CC=CC=C4)(O)CC2.CC(C=C7)=CC=C7[C@]5([C@](OC)=O)C[C@H]5CN6CCC(C8=CC=CC=C8)(O)CC6.O=C(O)C(O)=O.O=C(O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-PPCC oxalate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.95	100
	ethanol	4.7	10

Preparing Stock Solutions for (±)-PPCC oxalate

The following data is based on the product molecular weight 469.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.65 mL	21.30 mL
5 mM	0.43 mL	2.13 mL	4.26 mL
10 mM	0.21 mL	1.06 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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Reconstitution Calculator

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References for (±)-PPCC oxalate

References are publications that support the biological activity of the product.

Antonini Anti-amnesic properties of (±)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J.Neurochem. 2009 PMID: 19245662
Prezzavento A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. Life Sci. 2008 PMID: 18261749
Prezzavento Novel sigma receptor ligands: synthesis and biological profile. J.Med.Chem. 2007 PMID: 17328523

Citations for (±)-PPCC oxalate (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for (±)-PPCC oxalate include:

María et al. (2022) αN-Acetyl β-Endorphin Is an Endogenous Ligand of ς1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for ς2Rs in ς1R Oligomers. Int J Mol Sci. 24
PMID: 36614024
María et al. (2020) The ALS-related ς1R E102Q Mutant Eludes Ligand Control and Exhibits Anomalous Response to Calcium. Int J Mol Sci. 21
PMID: 33020464
Rodríguez-Muñoz et al. (2018) Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget. 9:23373
PMID: 29805740
Rodríguez-Muñoz et al. (2018) Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor. Mol Brain. 11:51
PMID: 30223868
Sánchez-Blázquez et al. (2018) Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice. Int J Neuropsychopharmacol. 21:938
PMID: 29860313
Malik et al. (2015) The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice. J Biol Chem. 172:2519
PMID: 25573298

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