±-MF 094
Tocris Bioscience, part of Bio-Techne | Catalog # 6718
Selective USP30 inhibitor
Key Product Details
Description
Selective USP30 inhibitor
Product Description
±-MF 904 is the racemate of MF 904, the S-enantiomer. The S-enantiomer is a selective USP30 (ubiquitin-specific-processing protease 30) inhibitor (IC50 = 120 nM). MF 094 increases protein ubiquitination and accelerates mitophagy.Product Specifications
Molecular Weight
535.70
Formula
C30H37N3O4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(1-((5-(N-(tert-Butyl)sulfamoyl)naphthalen-1-yl)amino)-1-oxo-3-phenylpropan-2-yl)cyclohexanecarboxamide
CAS Number
2758431-95-5
PubChem ID
146503417
InChI Key
DQXORJHBZHLLTE-UHFFFAOYSA-N
SMILES
CC(C)(NS(=O)(C1=CC=CC2=C1C=CC=C2NC(C(NC(C3CCCCC3)=O)CC4=CC=CC=C4)=O)=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.78 | 50 |
Preparing Stock Solutions
for ±-MF 094
The following data is based on the product molecular weight 535.70
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.73 mL | 18.67 mL | 37.33 mL |
| 2.5 mM | 0.75 mL | 3.73 mL | 7.47 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.73 mL |
| 25 mM | 0.07 mL | 0.37 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Li and Liu Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors. Eur.J.Med.Chem. 2020 PMID: 32092586
- Kluge Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg.Med.Chem.Lett. 2018 PMID: 29935771
Product Specific Notices for ±-MF 094
For research use only
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