±-MF 094

Name: ±-MF 094
Brand: Tocris Bioscience
SKU: 6718

Tocris Bioscience, part of Bio-Techne | Catalog # 6718

COA / SDS

Selective USP30 inhibitor

Key Product Details

Description:	Selective USP30 inhibitor
Chemical Name:	N-(1-((5-(N-(tert-Butyl)sulfamoyl)naphthalen-1-yl)amino)-1-oxo-3-phenylpropan-2-yl)cyclohexanecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	535.7

View Full Technical Details for ±-MF 094

Technical Data
Citations

Biological Activity for ±-MF 094

±-MF 904 is the racemate of MF 904, the S-enantiomer. The S-enantiomer is a selective USP30 (ubiquitin-specific-processing protease 30) inhibitor (IC₅₀ = 120 nM). MF 094 increases protein ubiquitination and accelerates mitophagy.

Technical Data for ±-MF 094

M. Wt	535.7
Formula	C₃₀H₃₇N₃O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2758431-95-5
PubChem ID	146503417
InChi Key	DQXORJHBZHLLTE-UHFFFAOYSA-N
Smiles	CC(C)(NS(=O)(C1=CC=CC2=C1C=CC=C2NC(C(NC(C3CCCCC3)=O)CC4=CC=CC=C4)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ±-MF 094

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.78	50

Preparing Stock Solutions for ±-MF 094

The following data is based on the product molecular weight 535.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.73 mL	18.67 mL	37.33 mL
2.5 mM	0.75 mL	3.73 mL	7.47 mL
5 mM	0.37 mL	1.87 mL	3.73 mL
25 mM	0.07 mL	0.37 mL	0.75 mL

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References for ±-MF 094

References are publications that support the biological activity of the product.

Li and Liu Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors. Eur.J.Med.Chem. 2020 PMID: 32092586
Kluge Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg.Med.Chem.Lett. 2018 PMID: 29935771