(±)-Epibatidine
Tocris Bioscience, part of Bio-Techne | Catalog # 0684
High affinity nAChR agonist
Key Product Details
Description
High affinity nAChR agonist
Product Description
(±)-Epibatidine is a high affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.Licensing Information
Sold under license from the NIH, US Patent 5,314,899Product Specifications
Molecular Weight
208.69
Formula
C11H13ClN2
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
(±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane
CAS Number
148152-66-3
PubChem ID
1204
InChI Key
NLPRAJRHRHZCQQ-UHFFFAOYSA-N
SMILES
ClC(N=C3)=CC=C3C2C1CCC(C2)N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.23 | 5 | |
| Ethanol | 24.55 | 100 |
Preparing Stock Solutions
for (±)-Epibatidine
The following data is based on the product molecular weight 208.69
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.79 mL | 23.96 mL | 47.92 mL |
| 5 mM | 0.96 mL | 4.79 mL | 9.58 mL |
| 10 mM | 0.48 mL | 2.40 mL | 4.79 mL |
| 50 mM | 0.10 mL | 0.48 mL | 0.96 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Spande Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity. J.Am.Chem.Soc.
- Sharples UB-165 implicates α4β2 nAChR in striatal DA release. J.Neurosci. 2000 PMID: 10751429
- Gerzarich Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors. Mol.Pharmacol. 1995 PMID: 7476906
- Marks Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain. J.Pharmacol.Exp.Ther. 1998 PMID: 9536034
- Badio and Daly Epibatidine, a potent analgesic and nicotinic agonist. Mol.Pharmacol. 1994 PMID: 8183234
Product Specific Notices for (±)-Epibatidine
For research use only
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