DL 175

Product Description

DL 175 is a potent and selective GPR84 biased agonist (EC₅₀ = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.

Solubility

Preparing Stock Solutions for DL 175

The following data is based on the product molecular weight 299.75

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.34 mL	16.68 mL	33.36 mL
5 mM	0.67 mL	3.34 mL	6.67 mL
10 mM	0.33 mL	1.67 mL	3.34 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lucy A biased agonist at immunometabolic receptor GPR84 causes distinct functional effects in macrophages. ACS Chem.Biol 2019 PMID: 31465201