Diprotin A

Name: Diprotin A
Brand: Tocris Bioscience
SKU: 6019

Tocris Bioscience, part of Bio-Techne | Catalog # 6019

Citations (5)

COA / SDS

Dipeptidyl peptidase IV (DPP-IV) inhibitor

Key Product Details

Description:	Dipeptidyl peptidase IV (DPP-IV) inhibitor
Alternative Names:	Ile-Pro-Ile
Chemical Name:	L-Isoleucyl-L-prolyl-L-isoleucine
Purity:	≥98% (HPLC)
Molecular Weight:	341.45

View Full Technical Details for Diprotin A

Technical Data
Citations

Biological Activity for Diprotin A

Diprotin A is a dipeptidyl peptidase IV (DPP-IV) inhibitor. Inhibits hydrolysis of incretins, regulating blood glucose levels. Induces Src and vascular endothelium-cadherin phosphorylation, increasing vascular permeability in the retina. Also increases number of viable phenotypic long term repopulating hematopoietic stem cells when harvesting mouse bone marrow in aerobic conditions.

Technical Data for Diprotin A

M. Wt	341.45
Formula	C₁₇H₃₁N₃O₄
Single Letter Sequence	IPI
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	90614-48-5
PubChem ID	94701
InChi Key	JNTMAZFVYNDPLB-PEDHHIEDSA-N
Smiles	O=C([C@@H](N)[C@@H](C)CC)N1[C@H](C(N[C@H](C(O)=O)[C@@H](C)CC)=O)CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Diprotin A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	34.15	100

Preparing Stock Solutions for Diprotin A

The following data is based on the product molecular weight 341.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.64 mL	29.29 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
10 mM	0.29 mL	1.46 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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References for Diprotin A

References are publications that support the biological activity of the product.

Lim Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation. Korean J.Intern.Med. 2015 PMID: 26552451
Lee Dipeptidyl peptidase-4 inhibitor increases vascular leakage in retina through VE-cadherin phosphorylation. Sci.Rep. 2016 PMID: 27381080
Juillerat-Jeanneret Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else? J.Med.Chem. 2014 PMID: 24099035