DIM-C-pPhOH

Name: DIM-C-pPhOH
Brand: Tocris Bioscience
SKU: 6377

Tocris Bioscience, part of Bio-Techne | Catalog # 6377

Citations (1)

COA / SDS

Nur77 antagonist

Key Product Details

Description:	Nur77 antagonist
Chemical Name:	1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane
Purity:	≥98% (HPLC)
Molecular Weight:	338.408

View Full Technical Details for DIM-C-pPhOH

Technical Data
Citations

Biological Activity for DIM-C-pPhOH

DIM-C-pPhOH is a Nur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines. Mimics effects of Nur77 RNAi silencing.

Technical Data for DIM-C-pPhOH

M. Wt	338.408
Formula	C₂₃H₁₈N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	151358-47-3
PubChem ID	2940609
InChi Key	QCPDFNWJBQMXLI-UHFFFAOYSA-N
Smiles	OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DIM-C-pPhOH

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.84	100
	ethanol	33.84	100

Preparing Stock Solutions for DIM-C-pPhOH

The following data is based on the product molecular weight 338.408.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.55 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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Reconstitution Calculator

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References for DIM-C-pPhOH

References are publications that support the biological activity of the product.

Hedrick NR4A1 antagonists inhibit 1-Integrin-dependent breast cancer cell migration. Mol.Cell.Biol 2016 PMID: 26929200
Lee The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Mol.Cancer Res. 2014 PMID: 24515801
Chintharlapalli Activation of Nur77 by selected 1,1-Bis(3-indolyl)-1- (p-substituted phenyl)methanes induces apoptosis through nuclear pathways. J.Biol.Chem 2005 PMID: 15871945