Diltiazem hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0685
CaV1.x blocker
Product Description
Diltiazem hydrochloride is an antihypertensive and cardioprotective agent; an inhibitor of L-type Ca2+ channels.Product Specifications
Molecular Weight
450.98
Formula
C22H26N2O4S.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
CAS Number
33286-22-5
PubChem ID
62920
InChI Key
HDRXZJPWHTXQRI-BHDTVMLSSA-N
SMILES
[H][C@]2(C3=CC=C(OC)C=C3)[C@@]([H])(OC(C)=O)C(N(CCN(C)C)C1=CC=CC=C1S2)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 | ||
| DMSO | 45.1 | 100 |
Preparing Stock Solutions
for Diltiazem hydrochloride
The following data is based on the product molecular weight 450.98
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.09 mL | 22.17 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.43 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kraus Molecular mechanisms of dilt. interaction with L-type Ca2+ channels. J.Biol.Chem. 1998 PMID: 9765241
- Gandia Inhibition of nicotinic receptor-mediated responses in bovine chromaffin cells by dilt. Br.J.Pharmacol. 1996 PMID: 8818357
- Ishibashi Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by dilt. and vera. Brain Res. 1995 PMID: 8574653
- Dagani Effects of dilt. on bioenergetics, K+ gradients, and free cytosolic Ca2+ levels in rat brain synaptosomes submitted to energy metabolism inhibition and depolarization. J.Neurochem. 1989 PMID: 2795006
Product Specific Notices for Diltiazem hydrochloride
For research use only
⚠ WARNING: This product can expose you to chemicals including Diltiazem hydrochloride , which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
Loading...
Loading...