Dihydroergotoxine mesylate

Name: Dihydroergotoxine mesylate
Brand: Tocris Bioscience
SKU: 0505

Tocris Bioscience, part of Bio-Techne | Catalog # 0505

COA / SDS

Binds to GABAA receptor Cl- channel; allosteric modulator of benzodiazepine site

Discontinued Product

0505 has been discontinued. View all GABA-A Receptor Benzodiazepines products.

Key Product Details

Description:

Binds to GABA_A receptor Cl^- channel; allosteric modulator of benzodiazepine site

View Full Technical Details for Dihydroergotoxine mesylate

Technical Data
Citations

Biological Activity for Dihydroergotoxine mesylate

Dihydroergotoxine mesylate is a complex of closely related alkaloid salts. Binds with high affinity to the GABA_A receptor Cl^- channel, producing an allosteric interaction with the benzodiazepine site. Also interacts with central dopaminergic, serotonergic and adrenergic (α₁) receptors. Displays antiproliferative activity in vitro (IC₅₀ = 18 - 38 μM in prostate cancer cells) and exhibits cognition-enhancing, anticonvulsant and sedative activity in vivo. Orally active.

Technical Data for Dihydroergotoxine mesylate

Storage	Store at RT
CAS Number	8067-24-1
PubChem ID	92044435
InChi Key	HMMYROQEJAZVGJ-CTOOOFERSA-N
Smiles	[H][C@]4([C@@]([H])3C[C@@H]([C@@](N[C@@]5([C@H](C)C)C(N([C@@]([H])([C@@H](C)C)C(N7[C@]([H])6CCC7)=O)[C@@]6(O)O5)=O)=O)CN4C)CC1=CNC2=C1C3=CC=C2.[H][C@]%11([C@@]([H])%10C[C@@H]([C@@](N[C@@]%12([C@H](C)C)C(N([C@@]([H])(CC%15=CC=CC=C%15)C(N%14[C@]([H])%13CCC%14)=O)[C@@]%13(O)O%12)=O)=O)CN%11C)CC8=CNC9=C8C%10=CC=C9.[H][C@]%19([C@@]([H])%18C[C@@H]([C@@](N[C@@]%20([C@H](C)C)C(N([C@@]([H])(CC(C)C)C(N%22[C@]([H])%21CCC%22)=O)[C@@]%21(O)O%20)=O)=O)CN%19C)CC%16=CNC%17=C%16C%18=CC=C%17.[H][C@]%26([C@@]([H])%25C[C@@H]([C@@](N[C@@]%27([C@H](C)C)C(N([C@@]([H])([C@@H](CC)C)C(N%29[C@]([H])%28CCC%29)=O)[C@@]%28(O)O%27)=O)=O)CN%26C)CC%23=CNC%24=C%23C%25=CC=C%24.CS(=O)(O)=O.CS(=O)(O)=O.CS(=O)(O)=O.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Dihydroergotoxine mesylate

References are publications that support the biological activity of the product.

Tvredic and Perici Effects of ergot alkaloids on 3H-flunitrazepam binding to mouse brain GABAA receptors. Coll.Antropol. 2003 PMID: 12955907
Tvrdeic and Perici Dihydrogenated ergot compounds bind with high affinity to GABA_A receptor-associated Cl^- ionophore. Eur.J.Pharmacol. 1991 PMID: 1664802
Tvrdeic and Perici Dihydroergotoxine modulation of the GABA_A receptor-associated Cl^- ionophore in mouse brain. Eur.J. Pharmacol. 1992 PMID: 1333969
Abdul Expression of gamma-aminobutyric acid receptor (subtype A) in prostate cancer Acta Oncol. 2008 PMID: 18607852

Dihydroergotoxine mesylate

Tocris Bioscience, part of Bio-Techne | Catalog # 0505

Key Product Details

Biological Activity for Dihydroergotoxine mesylate

Technical Data for Dihydroergotoxine mesylate

Dilution Calculator

Reconstitution Calculator

References for Dihydroergotoxine mesylate

Product Documents for Dihydroergotoxine mesylate

COA

Certificate of Analysis

SDS

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