Diclofenac sodium salt

Name: Diclofenac sodium salt
Brand: Tocris Bioscience
SKU: 4454

Tocris Bioscience, part of Bio-Techne | Catalog # 4454

Citations (3)

COA / SDS

Cyclooxygenase inhibitor; NSAID

Key Product Details

Description:	Cyclooxygenase inhibitor; NSAID
Chemical Name:	2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	318.13

View Full Technical Details for Diclofenac sodium salt

Technical Data
Citations

Biological Activity for Diclofenac sodium salt

Diclofenac sodium salt is a nonsteroidal, anti-inflammatory drug (NSAID); inhibits COX-1 and COX-2 (IC₅₀ values are 0.075 μM for COX-1 and 0.038 μM for COX-2 in human whole blood assay).

Technical Data for Diclofenac sodium salt

M. Wt	318.13
Formula	C₁₄H₁₀Cl₂NNaO₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	15307-79-6
PubChem ID	5018304
InChi Key	KPHWPUGNDIVLNH-UHFFFAOYSA-M
Smiles	[Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Diclofenac sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	15.91	50
	DMSO	31.81	100

Preparing Stock Solutions for Diclofenac sodium salt

The following data is based on the product molecular weight 318.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.14 mL	15.72 mL	31.43 mL
5 mM	0.63 mL	3.14 mL	6.29 mL
10 mM	0.31 mL	1.57 mL	3.14 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

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Reconstitution Calculator

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References for Diclofenac sodium salt

References are publications that support the biological activity of the product.

Bort Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. J.Pharmacol.Exp.Ther. 1998 PMID: 9862754
Laneuville Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J.Pharmacol.Exp.Ther. 1994 PMID: 7965814
Warner Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc.Natl.Acad.Sci.USA 1999 PMID: 10377455