DHC-156
Tocris Bioscience, part of Bio-Techne | Catalog # 8168
Brachyury down modulator
Key Product Details
Description
Brachyury down modulator
Product Description
DHC-156 is a brachyury down modulator (DC50 = 4.1 μM, DMax > 99% at 10 μM). DHC-156 down modulates brachyury post-translationally, in a proteasome- and lysosome-independent manner. DHC-156 down modulation of brachyury results in an irreversible impairment of chordoma tumor cell growth.Product Specifications
Molecular Weight
492.47
Formula
C24H24F4N4O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(E)-4-(Dimethylamino)-N-[1-[4-fluoro-3-(2,2,2-trifluoroethoxy)anilino]-6-methoxy-7-isoquinolyl]but-2-enamide
PubChem ID
171038043
InChI Key
SBZOWNJIUPEINK-SNAWJCMRSA-N
SMILES
COC1=C(C=C2C(NC3=CC(OCC(F)(F)F)=C(C=C3)F)=NC=CC2=C1)NC(/C=C/CN(C)C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.25 | 100 |
Preparing Stock Solutions
for DHC-156
The following data is based on the product molecular weight 492.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.03 mL | 10.15 mL | 20.31 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.03 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Chase Development of a small molecule downmodulator for the transcription factor brachyury. Angew.Chem.Int.Ed.Engl. 2024 PMID: 38348945
Product Specific Notices for DHC-156
For research use only
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