DFMO

Name: DFMO
Brand: Tocris Bioscience
SKU: 2761

Tocris Bioscience, part of Bio-Techne | Catalog # 2761

Citations (25)

COA / SDS

Ornithine decarboxylase inhibitor

Key Product Details

Description:	Ornithine decarboxylase inhibitor
Alternative Names:	Eflornithine
Chemical Name:	DL-2-(Difluoromethyl)-ornithine hydrochloride
Molecular Weight:	218.63

View Full Technical Details for DFMO

Technical Data
Citations

Biological Activity for DFMO

DFMO is an irreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs.

Technical Data for DFMO

M. Wt	218.63
Formula	C₆H₁₂F₂N₂O₂.HCl
Storage	Desiccate at RT
CAS Number	68278-23-9
PubChem ID	57004
InChi Key	VKDGNNYJFSHYKD-UHFFFAOYSA-N
Smiles	NC(C(F)F)(C(O)=O)CCCN.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DFMO

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	16.4	75

Preparing Stock Solutions for DFMO

The following data is based on the product molecular weight 218.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	6.10 mL	30.49 mL	60.99 mL
3.75 mM	1.22 mL	6.10 mL	12.20 mL
7.5 mM	0.61 mL	3.05 mL	6.10 mL
37.5 mM	0.12 mL	0.61 mL	1.22 mL

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Reconstitution Calculator

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References for DFMO

References are publications that support the biological activity of the product.

Carrillo Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase. Biochem.Biophys.Res.Comm.
Wu Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. Biochem.J. 2012 PMID: 22132744
Raul Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent. Biochem.Soc.Trans. 2007 PMID: 17371277